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KMID : 0861020090240030129
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Korea Journal of Herbology
2009 Volume.24 No. 3 p.129 ~ p.138
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Study on Antioxidant Effect of Hoveniae Semen cum Fructus and Hoveniae Ramulus on Liver Cells Isolated from Oxidatively Stressed Rat
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Choi Jeong-Kook
Han Hyo-Sang
Lee Young-Jong
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Abstract
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Objectives : The Objective of this study is to compare the anti-oxidative effect of the Hoveniae Semen cum Fructus (HScF) to that of Hoveniae Ramulus (HR) in vivo.
Methods : The extracts of HScF and HR were tested in vivo for their anti-oxidative effects. SD Rats were injected with the AAPH (2.2’-azobis (2-aminodinopropane) hydrochloride) to induce the acute oxidization stress, and the oxidized rats were administered with the HScF and HR decoction orally. The RBC, WBC and PLT populations in plasma, and the blood chemistry levels of the rats were measured to observe the overall changes in the blood. The anti-oxidative effects of the HScF and HR decoctions were investigated on the liver tissues of the oxidated rats.
Results : 1. Thrombocyte decreased significantly in the group medicated with HScF. 2. Blood glucose increased significantly in the group medicated with HR. 3. SOD activity increased significantly in both the group medicated with HScF and that with HR. 4. NO concentration decreased significantly in both the group medicated with HScF and that with HR. 5. The catalase content increased significantly in both the group medicated with HScF and that with HR.
Conclusions : The HScF and HR extracts have an anti-oxidative effect.
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KEYWORD
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Hovenia dulcis Thunb, Hoveniae Semen cum Fructus, Hoveniae Ramulus, antioxidative effect
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